Long-term protection of mice from Lyme disease by vaccination with OspA
نویسندگان
چکیده
منابع مشابه
Effects of OspA vaccination on Lyme disease serologic testing.
This study presents the effects of OspA vaccination on two-step testing for Borrelia burgdorferi antibodies. Although vaccinees developed enzyme-linked immunosorbent assay reactivity, immunoblots did not fulfill Centers for Disease Control and Prevention criteria for positivity. Furthermore, OspA reactivity did not interfere with interpretation of immunoblots with sera from patients who develop...
متن کاملEvaluation of OspA Vaccination-Induced Serological Correlates of Protection against Lyme Borreliosis in a Mouse Model
BACKGROUND For clinical development of a novel multivalent OspA vaccine against Lyme borreliosis, serological assays are required which can be used to establish immune correlates of protection against infection with Borrelia. METHODS Four assays (an OspA IgG ELISA, a competitive inhibition (CI) ELISA, a Borrelia surface-binding (SB) assay and a Borrelia killing assay) were used to evaluate th...
متن کاملRecombinant assay for serodiagnosis of Lyme disease regardless of OspA vaccination status.
All current seroassays using cultured Borrelia burgdorferi as their antigen source have been rendered obsolete by the recombinant OspA Lyme disease vaccine. OspA is the major outer surface protein expressed in cultured B. burgdorferi, and any seroassay that uses whole organisms as its antigen source cannot differentiate between subjects who received the vaccine and those who were naturally infe...
متن کاملEarly and specific antibody response to OspA in Lyme Disease.
Borrelia burgdorferi (Bb), the cause of Lyme disease, has appeared not to evoke a detectable specific antibody response in humans until long after infection. This delayed response has been a biologic puzzle and has hampered early diagnosis. Antibody to the abundant organism-specific outer surface proteins, such as the 31-kD OspA, has rarely been detected less than 6 mo after infection. Antibody...
متن کاملLong-term outcomes of persons with Lyme disease.
CONTEXT Few data exist about the long-term outcomes of patients with Lyme disease. OBJECTIVE To assess the long-term outcomes of patients with Lyme disease. DESIGN Two-part project including a community-based longitudinal cohort study and a matched cohort study. SETTING AND PARTICIPANTS Six hundred seventy-eight patients identified from a random sample of all reports of Connecticut reside...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1992
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.60.3.773-777.1992